Ryu can't focus through upair if Luma is alive, and his air speed is very poor. Thus his only real mixup is his double jump timing. Make sure you are spaced and drifting in such a way where even if he airdodges upair, he is trapped and gets hit by a follow-up upair. If you catch Ryu without a jump, Rosalina has the potential to juggle him for his entire stock.
Uptilt and Upsmash also will beat out anything Ryu has, including focus if Luma is alive. Be proactive in maintaining advantage state, as Ryu has very few options to deal with getting juggled by Rosalina.
Rosalina & Luma
Uptilt and Upsmash also will beat out anything Ryu has, including focus if Luma is alive. Be proactive in maintaining advantage state, as Ryu has very few options to deal with getting juggled by Rosalina.